The effect of ions of divalent metals on oligomerization and aggregation of amyloid ?-peptide - the main pathological factor in Alzheimer's disease

Project manager: Katarzyna Miranowicz-Dzierżawska Ph.D.

Project summary:

"The aim of this research task was to determine the influence of ions of divalent metals on structural processes and oligomerization of amyloid ?-peptide, which is the main pathological factor in Alzheimer's disease.The research task resulted in the creation of a unique method of investigating the interaction of metal ions with oligomeric forms A?1-40; individual proofs of preferentially built-in Cu(I) - Cu(II) dimers in soluble forms of the oligomeric A?-peptide have been presented. It was discovered that A? oligomers, which contain Cu(II) - Cu(II) dimers are present in greater quantities than those oligomers that do not contain them or contain one Cu(II) ion; that is why preferential ones are formed, even in conditions of limited access to Cu(II) ions, which precede Alzheimer's disease."

Unit: Department of Chemical and Aerosol Hazards

Duration: 01.01.2005 – 31.12.2007